Natural anti-inflammatory products and leukotriene inhibitors as complementary therap

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Clin Biochem. 2010 Jul;43(10-11):887-90. Epub 2010 Apr 27.

Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma.

Houssen ME, Ragab A, Mesbah A, El-Samanoudy AZ, Othman G, Moustafa AF, Badria FA.

Source

Department of Biochemistry, Faculty of Pharmacy, University of Beni Sueif, Beni Sueif 62514, Egypt. mahahoussen@yahoo.com

Abstract

OBJECTIVE:

To assess the efficacy of a combination of Boswellia serrata, licorice root (Glycyrrhiza glabra) and Tumeric root (Curcuma longa) as natural leukotriene inhibitor, antiinflammatory and antioxidant products respectively in controlling bronchial asthma.
SUBJECTS AND METHODS:

The study comprised 63 patients with bronchial asthma that are further subdivided into two groups .Group 1 receiving oral capsule (combined herb) in a soft-gelatin capsule 3 times daily for 4weeks and group 2 receiving placebo. Plasma leukotriene C(4) (LTC(4))(,) nitric oxide (NO) and malondialdehyde (MDA) levels were measured and pulmonary function was also assessed in all patients enrolled in the study.
RESULTS:

There was a statistically significant decrease in the plasma levels of LTC(4), (MDA), and NO in target therapy group when compared with placebo group.
CONCLUSION:

The used extract contained Boswellia serrata, Curcuma longa and Glycyrrhiza has a pronounced effect in the management of bronchial asthma.

Copyright 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.