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Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers
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James Offline
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Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers
Cancer Res. 1998 Sep 1;58(17):3761-4.

Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.

Hida T, Yatabe Y, Achiwa H, Muramatsu H, Kozaki K, Nakamura S, Ogawa M, Mitsudomi T, Sugiura T, Takahashi T.

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Department of Internal Medicine, Aichi Cancer Center Hospital, Nagoya, Japan.

Abstract

Cyclooxygenase (COX)-2 expression was immunohistochemically examined in 59 human lung cancers as well as in normal and premalignant lung specimens. In contrast to scattered weak reactivity seen in normal peripheral airway epithelial cells, markedly up-regulated COX-2 expression was detected in about one-third of atypical adenomatous hyperplasias and carcinoma in situ specimens, and a significant increase in COX-2 expression was observed in 70% of invasive adenocarcinoma cases. Interestingly, the proportion of adenocarcinoma cells with marked COX-2 expression was much greater in lymph node metastases than in the corresponding primary tumors. In contrast, small cell carcinomas showed virtually negligible expression, and squamous cell carcinomas showed infrequent and low expression. These findings suggest that an increase in COX-2 expression may be associated with the development of adenocarcinomas and possibly with acquisition of an invasive and metastatic phenotype.

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07-17-2012 11:34 AM
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James Offline
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Increased expression of COX-2 in the devele 2 occurs frequently in human lung cancers
J Environ Pathol Toxicol Oncol. 2002;21(2):177-81.

Increased expression of COX-2 in the development of human lung cancers.

Takahashi T, Kozaki K, Yatabe Y, Achiwa H, Hida T.

Source

Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan. tak@aichi-cc.pref.aichi.jp

Abstract

It is well accepted that an increase in the expression of cyclooxygenase-2 (COX-2), a key inducible enzyme involved in the production of prostaglandins and other eicosanoids, may play a significant role in carcinogenesis in addition to its well-known role in inflammatory reactions. Whereas previous studies were largely confined to colorectal tumorigenesis, we have shown that a significantly increased expression of COX-2 may also play a role in the development of lung cancer. COX-2 expression was found to be frequently elevated in lung cancer, especially in adenocarcinoma, and the proportion of lung cancer cells with marked COX-2 expression was much higher in lymph node metastases than in the corresponding primary tumors. It was also shown that early stage adenocarcinoma patients with increased COX-2 expression who were surgically treated had a shorter survival. Our studies, which used high- and low-metastatic human lung cancer cell sublines established in our laboratory, revealed an association between metastatic capabilities and COX-2 expression levels: COX-2-specific inhibitors could inhibit in vitro the invasion of the highly metastatic NCI-H460-LNM35 clone through Matrigel-containing basement membrane components as well as the spontaneous in vivo metastasis in SCID mice. Taken together, these findings suggest that an increase in COX-2 expression maybe associated with the development of lung cancer and possibly with the acquisition of an invasive and metastatic phenotype.

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07-17-2012 11:35 AM
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henrywronger Offline
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RE: Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers
Lung cancer is very dangerous disease. If you have lung cancer then you can not live for long time. Its treatment is very difficult. If you do smoking then you have this type of cancer so please quit smoking and save your life.
08-27-2012 11:54 AM
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James Offline
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RE: Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers
(08-27-2012 11:54 AM)henrywronger Wrote:  Lung cancer is very dangerous disease. If you have lung cancer then you can not live for long time. Its treatment is very difficult. If you do smoking then you have this type of cancer so please quit smoking and save your life.

Smoking is not the only factor increasing the risk of lung cancer. Radon gas and asbestos for example are just a few other factors.

Some lung cancers can be very rapid growing, which is why ozone therapy would be my first choice for this type of cancer.

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09-02-2012 07:02 PM
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