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Genistein-induced apoptosis in prostate cancer cells.
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James Offline

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Genistein-induced apoptosis in prostate cancer cells.
Nutr Cancer. 1998;32(3):123-31.

Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells.

Davis JN, Singh B, Bhuiyan M, Sarkar FH.


Department of Cancer Biology, Wayne State University School of Medicine, Harper Hospital, Detroit Medical Center, MI, USA.


Increased soy consumption in Asian diets, resulting in increased serum isoflavone levels, has been associated with a decreased risk for prostate adenocarcinoma (PCa). The isoflavone genistein is believed to be the anticancer agent found in soy, and significant levels of genistein have been detected in human prostatic fluid, implicating the role of genistein in PCa prevention. Recent studies have demonstrated genistein's ability to inhibit cell growth and induce apoptosis in several cell lines; however, the molecular mechanisms of genistein's effect are not known. We have evaluated the mechanism by which genistein may inhibit PCa cell growth. Here we report that genistein inhibits PCa cell growth in culture in a dose-dependent manner, which is accompanied by a G2/M cell cycle arrest. Cell growth inhibition was observed with concomitant downregulation of cyclin B, upregulation of the p21WAF1 growth-inhibitory protein, and induction of apoptosis. Collectively, these results provide experimental evidence for a novel effect of genistein on cell cycle gene regulation, resulting in the inhibition of cell growth and ultimate demise of tumor cells.
(This post was last modified: 07-17-2012 10:18 AM by James.)
07-17-2012 10:16 AM
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henrywronger Offline
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RE: Genistein-induced apoptosis in prostate cancer cells.
Prostate cancer is the most popular non-skin cancer and second only to lung cancer in cancer associated deaths. Occasionally this cancer can be small, slow developing and provide reduced risk to the sufferer while at other instances it can improvement rapidly showing great health risks. However with early prognosis, it can be efficiently treated and cured.
08-31-2012 03:05 PM
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