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Alkalinity promotes Candida overgrowth
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James Offline
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Alkalinity promotes Candida overgrowth

There is a very persistent myth that Candida albicans cannot survive a high (alkaline) pH. The fact is that C. albicans can survive very acid to extremely alkaline pH. The primary difference is the form it takes on dependent on the pH. At a low (acidic) pH C. albicans remains in a less pathogenic yeast form, and its growth is inhibited. When C. albicans is exposed to a high (alkaline) pH it promotes the formation of its hyphal growth. This hyphal growth allows C. albicans to not only become pathogenic, but also to allow it to invade deep in to tissues and to promote organ damage. This hyphal growth is inhibited at an acidic pH of 4 or below reducing tissue invasion and damage. I have compiled some research from non-commercial sites to prove these facts. The growth of C. albicans in an alkaline environment, as well as an acidic environment in a pH range of 2 to 10:


http://ec.asm.org/cgi/content/full/5/9/1550


http://www.pubmedcentral.nih.gov/article...tid=232444


http://www.ncbi.nlm.nih.gov/pubmed/15189...rom=pubmed


http://www.ncbi.nlm.nih.gov/pubmed/10629...d_RVDocSum


http://www.springerlink.com/content/06crgmq4x3nj2820/


"In vitro, C. albicans can thrive over a remarkably wide range of extracellular pH, at pH values of 2-10 (Odds 1988)". They also point out that alkalinity promotes hyphal growth of C. albicans.

http://www.springerlink.com/content/j5v6h012235h3576/


"Upon response to environmental stimuli C. albicans can switch between yeast-like and filamentous, hyphal growth. This allows C. albicans to generate niche specific responses, form biofilms, adhere, and invade epithelial tissues. "

It is this switch to the hyphal growth, from alkalinity, that allows C. albicans to become pathogenic by more readily invading tissues:

http://www.pubmedcentral.nih.gov/article...rtid=97632


http://www.cell.com/current-biology/abst...06)00252-1


Hyphal growth has been shown to be inhibited at the acidic pH of 4 in all strains of C. albicans showing that an acidic pH helps to prevent C. albicans from being pathogenic. An alkaline pH on the other hand promotes pathogenesis of C. albicans as it promotes hyphal growth. The article from the following link points out what I have been trying to explain to people for decades. Stomach acid helps to control pathogen growth, including Candida. The same applies to the skin, which is normally slightly on the acidic side. When the pH is raised to the alkaline side candidiasis of the skin is promoted.

http://www.pubmedcentral.nih.gov/article...id=1770313


"In tissue samples from mucosal surfaces with a non-acidic pH, such as the tongue, oesophagus, intestine, and most skin areas, filamentous forms of C albicans predominated, and most of them exhibited both 1H4 immunostaining and an invasive phenotype (fig 3A ). In internal organs having a non-acidic pH (liver, lung, heart, and thyroid) from patients with systemic candidiasis, variable numbers of yeast cells were found, together with hyphae or pseudohyphae in virtually all cases. In these tissues, both yeast and filamentous forms showed strong 1H4 immunoreactivity (fig 3B , C). In contrast, in those tissues with an acidic pH, such as the stomach and collecting ducts of the kidney, the predominant form of C albicans was the blastospore (yeast). Interestingly, in these locations yeast cells essentially showed no 1H4 immunoreactivity (fig 3D , E). However, when adjacent tissue invasion was present, hyphae or pseudohyphae were the predominant form."

"The ability to undergo transition from the yeast to the hyphal form appears to be crucial in the pathogenesis of invasive candidiasis. 4– 6 Both yeast cells and hyphae are found in infected tissues and contribute to pathogenesis. Yeast cells are better suited for rapid haematogenous dissemination, but together with hyphal elements they are also capable of breaching epithelial and endothelial barriers to cause extensive organ damage. 4 During the infectious process, yeast cells and hyphae may encounter different microenvironments within the host. At acidic pH, C albicans grows mostly in the yeast form; at an alkaline pH, it grows primarily in the filamentous form. 2, 6, 7 Gastric acid provides an effective barrier to most microorganisms (normal gastric pH values are 1–3.5). In contrast, achlorhydria and the use of H2 antagonists, which raise gastric pH, have been found to be associated with a higher proportion of invasive gastric candidiasis. 17 Similarly, although the skin is relatively inhospitable to fungal growth, 18 the experimental increase of skin surface pH yields more pronounced cutaneous candidiasis in human volunteers. 19"

http://www.MountainMistBotanicals.com
07-01-2012 10:42 PM
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James Offline
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RE: Alkalinity promotes Candida overgrowth
More associated information:

As I have pointed out numerous times women in particular get yeast infections after antibiotic therapy because of the shift in vaginal pH to the alkaline side. The normal pH of the vagina is slightly acid, which helps to prevent Candida overgrowth as well as other pathogens. This is because most pathogens cannot survive an acidic environment. The acidity comes from beneficial Lactobacillus bacteria (flora) that produce lactic, acetic and fatty acids. When a woman takes antibiotics the flora are destroyed and the acids not being produced in sufficient quantities to maintain the proper acidic pH. When the pH is shifted to the alkaline side as I pointed out in my earlier post the Candida converts from a mild yeast form in to a more virulent and pathogenic form. Thus the Candida overgrowth.

http://www.MountainMistBotanicals.com
07-01-2012 10:44 PM
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James Offline
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RE: Alkalinity promotes Candida overgrowth
More evidence that acids control Candida:


http://www.arltma.com/CandidaNews.htm

"Acidity and candida. Yeast thrives in an alkaline environment. Gastric hydrochloric acid deficiency is widespread and allows yeast to survive passage through the stomach. The colon and vagina should be slightly acid, which would discourage yeast growth. However, in many people they are alkaline due to improper bowel flora, enzyme deficiencies and diets high in fruit and other carbohydrates."


http://www.drlwilson.com/articles/candida.htm

"Slow metabolism, deficient acid in the stomach, an over-alkaline intestinal tract and copper imbalance allow candida to flourish in the body. Weak adrenals, improper bowel flora, diets high in sugar and taking antibiotics, antacids, birth control pills and steroid hormones contribute to candida infection."

More from the above site:

"CAUSES - SLOW METABOLISM

In their order of importance, causes include slow metabolism, copper imbalance, alkaline intestines and tissues, medications, high carbohydrate diets and other toxins. Most people with candida are slow metabolizers. While their cells are more acidic, their intercellular spaces are too alkaline. Their bodies do not generate enough acid end products of metabolism such as lactic acid. Calcium, an alkaline-forming element, also builds up adding to the alkalinity. Candida thrives in an alkaline environment and becomes able to invade tissues and cause serious illness.

Slow metabolizers are also often deficient in hydrochloric acid. Stomach acid normally kills candida. This is one reason acidophilus, an acid-forming organism, often helps alleviate candida."

"Antibiotic overuse ranks high as a cause for candida. Acidophilus and other friendly yeasts help maintain an acidic intestinal environment. Antibiotics often kill acidophilus. E. coli and other bacteria replace the friendly organisms and produce an alkaline environment in which candida thrives."

"Antacids and other drugs that reduce acid may worsen candida by creating a deficiency of stomach acid. Ulcers and heartburn are often due to wheat allergy or factors other than excess stomach acid. Antacid drugs include Prilosec, Prevacid, Zantac, Pepcid, Tagamet, Mylanta, Malox, Gaviscon, Riopan, Rolaids, Tums, Nexium and others. Birth control pills and steroid drugs such as cortisone or prednisone also contribute to candida."


http://iai.asm.org/cgi/reprint/72/11/6206.pdf

LAB stands for lactic acid bacteria "LAB are also known to inhibit C. albicans colonization of the epithelium of the gastrointestinal tract in mice and subsequent hyphal invasion and systemic infection (45)."


http://www.candida-albicans-cure.com/probiotics.html

"Lactic Acid *
Acetic Acid *
Short Chain Fatty Acids *
These 3 lower the intestinal pH - making it too acidic for Candida to thrive"

http://www.MountainMistBotanicals.com
07-01-2012 10:49 PM
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