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Bacterial infections as one casue of IC? - James - 03-07-2013 04:25 PM

The cause of IC is not known, but bacterial infection has infection has been proposed by some researchers:

http://www.ncbi.nlm.nih.gov/pubmed/8284843

http://www.ncbi.nlm.nih.gov/pubmed/7855970

http://www.ncbi.nlm.nih.gov/pubmed/17036170

http://www.ncbi.nlm.nih.gov/pubmed/7869536


Bacterial cystitis is considered one possible precursor for IC. In short the hypothesis is the bacterial cystitis leads to damage of the bladder epithelium. This in turn leads to leaking of potassium in to the interstitium leading to mast cell activation and histamine release as well as release of substance P and immune reactions. All these lead increased damage to the bladder leading to increased interstitial potassium continuing the cycle.